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They are not FDA-approved for general human therapeutic application

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S1, S3, and S4)

Prognosis is shaped by how these injuries interact cumulative volume, pressure, swelling, and location matter more than any one lesion alone

324 A study also utilized platelet-derived exosomes loaded with recombinant Yap 1 protein delivered to TDSCs, which significantly protected TDSCs from oxidative stress-induced stemness loss and SASP via the NF-B signaling pathway

It is important to note that most patients in the trial opted for continuing on tamoxifen treatment in an open label extension phase of the clinical trial